This is a list and explanation of the genetic tests that we do on our parents.
None of our puppies will be at risk for any of these genetic diseases.
Copies of our parents genetic tests are available upon request.
This is a list and explanation of the genetic tests that we do on our parents.
None of our puppies will be at risk for any of these genetic diseases.
Copies of our parents genetic tests are available upon request.
Degenerative Myelopathy, DM (SOD1A)
Brain and Spinal Cord (Neurologic)
Gene: SOD1(A)
Inheritance type: recessive
The dog equivalent of Amyotrophic Lateral Sclerosis, or Lou Gehrig’s disease, DM is a progressive degenerative disorder of the spinal cord. Because the nerves that control the hind limbs are the first to degenerate, the most common clinical signs are back muscle wasting and gait abnormalities.
Exercise-Induced Collapse, EIC (DNM1)
Muscular (Muscular)
Gene: DNM1
Inheritance type: recessive
EIC has been linked to a mutation in the DNM1 gene, which codes for the protein dynamin. In the neuron, dynamin trucks neurotransmitter-filled vesicles from the cell body, where they are generated, to the dendrites. It is hypothesized in dogs affected with EIC, the mutation in DNM1 disrupts efficient neurotransmitter release, leading to a cessation in signalling and EIC.
Von Willebrand Disease Type I, Type I vWD (VWF)
Blood (Hematologic)
Gene: VWF
Inheritance type: recessive
Von Willebrand Disease (vWD) is a type of coagulopathy, a disorder of blood clotting. vWD is characterized into three types based on clinical severity, serum levels of vWF, and vWF multimer composition. Dogs with Type I vWD have low vWF levels, normal multimer composition, and variable clinical signs.